ARNA had a diet pill FDA advisory panel approved on May 11, resulting in a 73% gap up. On both days prior to the gap up, big volume up days can be seen as a clue.
But high volume up days preceding a major decision are no guarantee of final FDA approval, so keep that in mind with respect to any stock including VVUS.
Likewise, down volume days preceding a major decision is not necessarily a bad omen. ARNA sold off for 3 days prior to its diet pill receiving full FDA approval on June 27, 2012, causing the stock to rocket nearly 30%.
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